Crystal engineering Is the process for Making Co-Crystals
Solubility and Co-crystals
Fluoxetine HCl
Childs, S. L. et. al. J. Am. Chem. Soc., 126, 1335, 2004
Itraconazole
Marketed as a soluble amorphous phase
Bioavailability and Co-crystals
2-[4-(4-chloro-2-fluorophenoxy) phenyl]pyrimidine-4-carboxamide-glutaric acid cocrystal
Carbamazepine-saccharin
McNamara, D. P. et al. Pharm. Res., 23, 1888, 2006
Hickey, M. B. et al. Eur. J. Pharm. Biopharm., 67, 112, 2007
Permeability and co-crystals
Maleate salt, 1
Fumaric acid cocrystal dihydrate, 2
Glutaric acid cocrystal, 3
Acyclovir
Glutaric acid cocrystals improve permeability of acyclovir
Yan, Y. et al. CrystEngComm, 15, 6457, 2013
Drug-drug Co-crystals
Anti-HIV Drugs Lamivudine and Zidovudine
Lamivudine was approved by the FDA in 1995 in combination with Zidovudine
Lamivudine
Zidovudine
Lamivudine-zidovudine cocrystal hydrate
Bhatt, P. M. et al. Cryst. Growth Des., 9, 951, 2009
Tableting properties and Co-crystals. Voriconazole
Molecular packing of VOR and its salts Projection along slip planes
Tuning mechanical properties of pharmaceutical cocrystals
Mishra, M. K et al. Mol. Pharmaceutics, 2015
Representative P-h curves obtained on VOR and its (a) salts and (b) cocrystals